Objective: Psoriatic Disease (psoriasis - psoriatic arthritis) is an inflammatory systemic condition associated to obesity.Weight loss improves clinical severity. Mediterranean Diet (MD) has been considered a model of healthy and a very low-calorie ketogenic diet (VLCKD) is more effective for losing weight fast in obese. The study aims to determine the effectiveness of the MD and the VLCKD in the treatment of patients with inflammatory disease.

Patients and Methods: Twenty patients were identified as overweight and obese from 1^st to 3^rd degree using Body Mass Index (BMI). MD has been proposed to overweight patients while obese patients could choose between MD and VLCKD, according to their attitudes. Then, they were divided into two study groups (MD group and KD group).

Results: At baseline and after four weeks, we collected weight, BMI, waist circumference (WC) and body composition through bioimpedance analysis (BIA - Bioelectrical Impedance Analysis). At the end, both of dietary interventions were effective to improve all parameters, but we found a greater and significative reduction of BMI and WC, and more reduction of fat mass (FM) in KD group than MD group.

Conclusions: Preliminary data show that KD could be proposed as a first dietary intervention to obtain a rapid weight loss and maintenance of lean mass.