Injection therapy in hip osteoarthritis: one year in review

  • Mirian De Souza Department of Rheumatology and Clinical Sciences, Clinical Rheumatology Unit, ASST G. Pini-CTO, Milan; Department of Clinical Science and Community Health, University of Milan, Milan, Italy.
  • Alessandro Sinelli Department of Rheumatology and Clinical Sciences, Clinical Rheumatology Unit, ASST G. Pini-CTO, Milan; Department of Clinical Science and Community Health, University of Milan, Milan, Italy. https://orcid.org/0000-0001-6457-2540
  • Orazio De Lucia | orazio.delucia@asst-pini-cto.it Department of Rheumatology and Clinical Sciences, Clinical Rheumatology Unit, ASST G. Pini-CTO, Milan, Italy. https://orcid.org/0000-0003-2304-6661

Abstract

Hip osteoarthritis affects a substantial and growing number of people worldwide. Its incidence and prevalence are increasing due to ageing and obesity. It is estimated that it affects between 10 and 18% of individuals over 60 years of age and up to 1 in 3 patients over the age of 85 with a substantial proportion of them experiencing persistent pain, loss of function and decline in health-related quality of life. Our work was aimed at updating the latest data on this field. We searched the following terms on PubMed: ‘injection therapy’, ‘osteoarthritis’ and ‘hip’. We limited our search to the period from 1-1-2018 until 22-6-2019 and to the English language. We retrieved 31 works. We decided to divide the works into three groups: hyaluronic acid in hip OA, other therapies in hip OA and emerging radiological techniques to measure the efficacy of injection therapy. So far, in the literature there is no solid evidence that supports the efficacy of intra-articular infiltration therapies in hip osteoarthritis. The international guidelines reflect this lack of solid scientific evidence. We believe that only original works that show high-level evidence can highlight the benefits of these therapies.

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References

Murphy LB, Helmick CG, Schwartz TA, Renner JB, Tudor G, Koch GG, et al. One in four people may develop symptomatic hip osteoarthritis in his or her lifetime. Osteoarthr. Cartil. 2010;18:1372–9. DOI: https://doi.org/10.1016/j.joca.2010.08.005

McDonough CM, Jette AM. The Contribution of Osteoarthritis to Functional Limitations and Disability. Clinics in Geriatric Medicine 2010;26:387–99. DOI: https://doi.org/10.1016/j.cger.2010.04.001

Moreland, LW. Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action. Arthritis Res Ther 2003;5:64–7. DOI: https://doi.org/10.1186/ar623

Rutjes AWS, Jüni P, da Costa BR, Trelle S, Nüesch E, Reichenbach S. Viscosupplementation for Osteoarthritis of the Knee: A Systematic Review and Meta-analysis. Ann Intern Med 2012;157:180. DOI: https://doi.org/10.7326/0003-4819-157-3-201208070-00473

Clementi D, D’Ambrosi R, Bertocco P, Bucci MS, Cardile C, Ragni P, et al. Efficacy of a single intra-articular injection of ultra-high molecular weight hyaluronic acid for hip osteoarthritis: a randomized controlled study. Eur J Orthop Surg Traumatol 2018;28:915–22. DOI: https://doi.org/10.1007/s00590-017-2083-9

Brander V, Skrepnik N, Petrella RJ, Jiang G-L, Accomando B, Vardanyan A. Evaluating the use of intra-articular injections as a treatment for painful hip osteoarthritis: a randomized, double-blind, multicenter, parallel-group study comparing a single 6-mL injection of hylan G-F 20 with saline. Osteoarthritis and Cartilage 2019;27:59–70. DOI: https://doi.org/10.1016/j.joca.2018.08.018

Zhang W, Robertson J, Jones AC, Dieppe PA, Doherty M. The placebo effect and its determinants in osteoarthritis: meta-analysis of randomised controlled trials. Annals of the Rheumatic Diseases 2008;67:1716–23. DOI: https://doi.org/10.1136/ard.2008.092015

Bannuru RR, McAlindon TE, Sullivan MC, Wong JB, Kent DM, Schmid CH. Effectiveness and Implications of Alternative Placebo Treatments: A Systematic Review and Network Meta-analysis of Osteoarthritis Trials. Ann Intern Med 2015;163:365. DOI: https://doi.org/10.7326/M15-0623

Pogliacomi F, Schiavi P, Paraskevopoulos A, Leigheb M, Pedrazzini A, Ceccarelli F, et al. When is indicated viscosupplementation in hip osteoarthritis? Acta Bio Medica Atenei Parmensis 2018;90:67–74.

Ye Y, Zhou X, Mao S, Zhang J, Lin B. Platelet rich plasma versus hyaluronic acid in patients with hip osteoarthritis: A meta-analysis of randomized controlled trials. International Journal of Surgery 2018;53:279–87. DOI: https://doi.org/10.1016/j.ijsu.2018.03.078

Leite VF, Daud Amadera JE, Buehler AM. Viscosupplementation for Hip Osteoarthritis: A Systematic Review and Meta-Analysis of the Efficacy on Pain and Disability, and the Occurrence of Adverse Events. Archives of Physical Medicine and Rehabilitation 2018;99:574-583.e1. DOI: https://doi.org/10.1016/j.apmr.2017.07.010

Migliore A, Massafra U, Bizzi E, Vacca F, Martin-Martin S, Granata M, et al. Comparative, double-blind, controlled study of intra-articular hyaluronic acid (Hyalubrix®) injections versus local anesthetic in osteoarthritis of the hip. Arthritis Res Ther 2009;11:R183. DOI: https://doi.org/10.1186/ar2875

Lieberman JR, Engstrom SM, Solovyova O, Au C, Grady JJ. Is Intra-Articular Hyaluronic Acid Effective in Treating Osteoarthritis of the Hip Joint? The Journal of Arthroplasty 2015;30:507–11. DOI: https://doi.org/10.1016/j.arth.2013.10.019

Wu B, Li Y-M, Liu Y-C. Efficacy of intra-articular hyaluronic acid injections in hip osteoarthritis: a meta-analysis of randomized controlled trials. Oncotarget [Internet] 2017 [cited 2019 Dec 18];8. Available from: http://www.oncotarget.com/fulltext/20995 DOI: https://doi.org/10.18632/oncotarget.20995

Hochberg MC, Altman RD, April KT, Benkhalti M, Guyatt G, McGowan J, et al. American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. Arthritis Care Res 2012;64:465–74. DOI: https://doi.org/10.1002/acr.21596

Bannuru RR, Osani MC, Vaysbrot EE, Arden NK, Bennell K, Bierma-Zeinstra SMA, et al. OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis. Osteoarthritis and Cartilage 2019;S1063458419311161. DOI: https://doi.org/10.1016/j.joca.2019.06.011

American Academy of Orthopaedic Surgeons. Management of osteoarthritis of the hip. Evidence-based clinical practice guideline. 2017;

Conrozier T, Monfort J, Chevalier X, Raman R, Richette P, Diraçoglù D, et al. EUROVISCO Recommendations for Optimizing the Clinical Results of Viscosupplementation in Osteoarthritis. CARTILAGE 2018;194760351878345. DOI: https://doi.org/10.1177/1947603518783455

Paskins Z, Hughes G, Myers H, Hughes E, Hennings S, Cherrington A, et al. A randomised controlled trial of the clinical and cost-effectiveness of ultrasound-guided intra-articular corticosteroid and local anaesthetic injections: the hip injection trial (HIT) protocol. BMC Musculoskelet Disord 2018;19:218. DOI: https://doi.org/10.1186/s12891-018-2153-0

Walter WR, Bearison C, Slover JD, Gold HT, Gyftopoulos S. Clinical and patient-reported outcomes after image-guided intra-articular therapeutic hip injections for osteoarthritis-related hip pain: a retrospective study. Skeletal Radiol 2019;48:713–9. DOI: https://doi.org/10.1007/s00256-018-3113-3

Lai WC, Arshi A, Wang D, Seeger LL, Motamedi K, Levine BD, et al. Efficacy of intraarticular corticosteroid hip injections for osteoarthritis and subsequent surgery. Skeletal Radiol 2018;47:1635–40. DOI: https://doi.org/10.1007/s00256-018-3052-z

Hess SR, O’Connell RS, Bednarz CP, Waligora AC, Golladay GJ, Jiranek WA. Association of rapidly destructive osteoarthritis of the hip with intra-articular steroid injections. Arthroplasty Today 2018;4:205–9. DOI: https://doi.org/10.1016/j.artd.2017.12.002

Ebell MH. Osteoarthritis: Rapid Evidence Review. Am Fam Physician 2018;97:523–6.

Fernandes L, Hagen KB, Bijlsma JWJ, Andreassen O, Christensen P, Conaghan PG, et al. EULAR recommendations for the non-pharmacological core management of hip and knee osteoarthritis. Ann Rheum Dis 2013;72:1125. DOI: https://doi.org/10.1136/annrheumdis-2012-202745

Northumbria Healthcare NHS Foundation Trust, North Shields, United Kingdom, Ali M, Mohamed A, Health Education North East, Newcastle, United Kingdom, Elamin Ahmed H, South Tyneside District Hospital, South Shields, United Kingdom, et al. The use of ultrasound-guided platelet-rich plasma injections in the treatment of hip osteoarthritis: a systematic review of the literature. J Ultrason 2018;18:332–7. DOI: https://doi.org/10.15557/JoU.2018.0048

Tassara M, De Ponti A, Barzizza L, Zambelli M, Parisi C, Milani R, et al. Autologous conditioned serum (ACS) for intra-articular treatment in Osteoarthritis: Retrospective report of 28 cases. Transfus. Apher. Sci. 2018;57:573–7.

Centeno C, Pitts J, Al-Sayegh H, Freeman M. Efficacy of Autologous Bone Marrow Concentrate for Knee Osteoarthritis with and without Adipose Graft. BioMed Research International 2014;2014:1–9. DOI: https://doi.org/10.1155/2014/370621

Centeno CJ, Al-Sayegh H, Bashir J, Goodyear S, Freeman MD. A dose response analysis of a specific bone marrow concentrate treatment protocol for knee osteoarthritis. BMC Musculoskelet Disord 2015;16:258. DOI: https://doi.org/10.1186/s12891-015-0714-z

Darrow M, Shaw B, Darrow B, Wisz S. Short-Term Outcomes of Treatment of Hip Osteoarthritis With 4 Bone Marrow Concentrate Injections: A Case Series. Clin Med Insights Case Rep 2018;11:117954761879157. DOI: https://doi.org/10.1177/1179547618791574

Eleopra R, Rinaldo S, Lettieri C, Santamato A, Bortolotti P, Lentino C, et al. AbobotulinumtoxinA: A New Therapy for Hip Osteoarthritis. A Prospective Randomized Double-Blind Multicenter Study. Toxins (Basel) 2018;10. DOI: https://doi.org/10.3390/toxins10110448

Marchini C, Acler M, Bolognari MA, Causero A, Volpe D, Regis D, et al. Efficacy of botulinum toxin type A treatment of functional impairment of degenerative hip joint: Preliminary results. J Rehabil Med 2010;42:691–3. DOI: https://doi.org/10.2340/16501977-0546

Courseau M, Salle PV, Ranoux D, de Pouilly Lachatre A. Efficacy of Intra-Articular Botulinum Toxin in Osteoarticular Joint Pain: A Meta-Analysis of Randomized Controlled Trials. Clin J Pain 2018;34:383–9. DOI: https://doi.org/10.1097/AJP.0000000000000538

Ferrero G, Sconfienza LM, Fiz F, Fabbro E, Corazza A, Dettore D, et al. Effect of intra-articular injection of intermediate-weight hyaluronic acid on hip and knee cartilage: in-vivo evaluation using T2 mapping. Eur Radiol 2018;28:2345–55. DOI: https://doi.org/10.1007/s00330-017-5186-0

Deseyne N, Conrozier T, Lellouche H, Maillet B, Weber U, Jaremko JL, et al. Hip Inflammation MRI Scoring System (HIMRISS) to predict response to hyaluronic acid injection in hip osteoarthritis. Joint Bone Spine 2018;85:475–80. DOI: https://doi.org/10.1016/j.jbspin.2017.08.004

Steer KJD, Bostick GP, Woodhouse LJ, Nguyen TT, Schankath A, Lambert RGW, et al. Can effusion-synovitis measured on ultrasound or MRI predict response to intra-articular steroid injection in hip osteoarthritis? Skeletal Radiol. 2019;48:227–37. DOI: https://doi.org/10.1007/s00256-018-3010-9

Published
2020-04-24
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Issue
Section
Reviews
Keywords:
Hip osteoarthritis, injection, hyaluronic acid, steroid injection.
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How to Cite
De Souza, M., Sinelli, A., & De Lucia, O. (2020). Injection therapy in hip osteoarthritis: one year in review. Beyond Rheumatology, 2(1), 20-25. https://doi.org/10.4081/br.2020.22